TY - JOUR
T1 - A successful surgical case of a hypothalamic hamartoma with gelastic seizure
T2 - A case report
AU - Fujita, Tomoaki
AU - Nishimura, Shinjitsu
AU - Sakata, Hiroyuki
AU - Furuno, Yuichi
AU - Mino, Masaki
AU - Hori, Emiko
AU - Kaimori, Mitsuomi
AU - Shirane, Reizou
AU - Nishijima, Michiharu
PY - 2009/8
Y1 - 2009/8
N2 - Gelastic seizure is a rare form of epilepsy defined as automatic bouts of laughter without mirth commonly associated with a hypothalamic hamartoma. Surgical treatment of hypothalamic hamartomas is associated with a high risk of complications because of the close vicinity of adjacent structures such as the optic tracts and mammillary bodies. This case was an 11-year-old girl who presented with gelastic seizure and complicated partial seizure. She developed gelastic seizure at a frequency of 10 bouts per day. She was found to have an elliptical mass close to the left hypothalamus. The signal intensity on magnetic resonance imaging (MRI) was consistent with hypothalamic hamartoma. The patient underwent surgical resection by a subtemporal approach. Pathological findings confirmed the diagnosis of hypothalamic hamartoma. Postoperative MRI demonstrated that the hypothalamic hamartoma was successfully resected. Twenty four months after surgery, complicated partial seizure in this patient has improved to Engel's class Ia and gelastic seizure has improved to Engel's class IIIa.
AB - Gelastic seizure is a rare form of epilepsy defined as automatic bouts of laughter without mirth commonly associated with a hypothalamic hamartoma. Surgical treatment of hypothalamic hamartomas is associated with a high risk of complications because of the close vicinity of adjacent structures such as the optic tracts and mammillary bodies. This case was an 11-year-old girl who presented with gelastic seizure and complicated partial seizure. She developed gelastic seizure at a frequency of 10 bouts per day. She was found to have an elliptical mass close to the left hypothalamus. The signal intensity on magnetic resonance imaging (MRI) was consistent with hypothalamic hamartoma. The patient underwent surgical resection by a subtemporal approach. Pathological findings confirmed the diagnosis of hypothalamic hamartoma. Postoperative MRI demonstrated that the hypothalamic hamartoma was successfully resected. Twenty four months after surgery, complicated partial seizure in this patient has improved to Engel's class Ia and gelastic seizure has improved to Engel's class IIIa.
KW - Gelastic seizure
KW - Hypothalamic hamartoma
KW - Surgical treatment
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M3 - Article
C2 - 19663336
AN - SCOPUS:69749114822
VL - 37
SP - 781
EP - 785
JO - Neurological Surgery
JF - Neurological Surgery
SN - 0301-2603
IS - 8
ER -