TY - JOUR
T1 - A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
AU - Matsumoto, Sen
AU - Sakata, Yasuhiko
AU - Nakatani, Daisaku
AU - Suna, Shinichiro
AU - Mizuno, Hiroya
AU - Shimizu, Masahiko
AU - Usami, Masaya
AU - Sasaki, Tatsuya
AU - Sato, Hiroshi
AU - Kawahara, Yukio
AU - Hamasaki, Toshimitsu
AU - Nanto, Shinsuke
AU - Hori, Masatsugu
AU - Komuro, Issei
PY - 2012/10/19
Y1 - 2012/10/19
N2 - To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.
AB - To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.
KW - Acute myocardial infarction
KW - Circulating microRNAs
KW - Secondary prevention
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UR - http://www.scopus.com/inward/citedby.url?scp=84867870687&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2012.09.039
DO - 10.1016/j.bbrc.2012.09.039
M3 - Article
C2 - 22995291
AN - SCOPUS:84867870687
VL - 427
SP - 280
EP - 284
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -