A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

Sen Matsumoto, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Hiroya Mizuno, Masahiko Shimizu, Masaya Usami, Tatsuya Sasaki, Hiroshi Sato, Yukio Kawahara, Toshimitsu Hamasaki, Shinsuke Nanto, Masatsugu Hori, Issei Komuro

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalBiochemical and biophysical research communications
Volume427
Issue number2
DOIs
Publication statusPublished - 2012 Oct 19
Externally publishedYes

Keywords

  • Acute myocardial infarction
  • Circulating microRNAs
  • Secondary prevention

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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