A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

Sen Matsumoto; Yasuhiko Sakata; Daisaku Nakatani; Shinichiro Suna; Hiroya Mizuno; Masahiko Shimizu; Masaya Usami; Tatsuya Sasaki; Hiroshi Sato; Yukio Kawahara; Toshimitsu Hamasaki; Shinsuke Nanto; Masatsugu Hori; Issei Komuro

doi:10.1016/j.bbrc.2012.09.039

A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

Sen Matsumoto, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Hiroya Mizuno, Masahiko Shimizu, Masaya Usami, Tatsuya Sasaki, Hiroshi Sato, Yukio Kawahara, Toshimitsu Hamasaki, Shinsuke Nanto, Masatsugu Hori, Issei Komuro

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380^* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.

Original language	English
Pages (from-to)	280-284
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	427
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2012.09.039
Publication status	Published - 2012 Oct 19
Externally published	Yes

Keywords

Acute myocardial infarction
Circulating microRNAs
Secondary prevention

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2012.09.039

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Matsumoto, S., Sakata, Y., Nakatani, D., Suna, S., Mizuno, H., Shimizu, M., Usami, M., Sasaki, T., Sato, H., Kawahara, Y., Hamasaki, T., Nanto, S., Hori, M., & Komuro, I. (2012). A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction. Biochemical and biophysical research communications, 427(2), 280-284. https://doi.org/10.1016/j.bbrc.2012.09.039

A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction. / Matsumoto, Sen; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Mizuno, Hiroya; Shimizu, Masahiko; Usami, Masaya; Sasaki, Tatsuya; Sato, Hiroshi; Kawahara, Yukio; Hamasaki, Toshimitsu; Nanto, Shinsuke; Hori, Masatsugu; Komuro, Issei.

In: Biochemical and biophysical research communications, Vol. 427, No. 2, 19.10.2012, p. 280-284.

Research output: Contribution to journal › Article › peer-review

Matsumoto, S, Sakata, Y, Nakatani, D, Suna, S, Mizuno, H, Shimizu, M, Usami, M, Sasaki, T, Sato, H, Kawahara, Y, Hamasaki, T, Nanto, S, Hori, M & Komuro, I 2012, 'A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction', Biochemical and biophysical research communications, vol. 427, no. 2, pp. 280-284. https://doi.org/10.1016/j.bbrc.2012.09.039

Matsumoto, Sen ; Sakata, Yasuhiko ; Nakatani, Daisaku ; Suna, Shinichiro ; Mizuno, Hiroya ; Shimizu, Masahiko ; Usami, Masaya ; Sasaki, Tatsuya ; Sato, Hiroshi ; Kawahara, Yukio ; Hamasaki, Toshimitsu ; Nanto, Shinsuke ; Hori, Masatsugu ; Komuro, Issei. / A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction. In: Biochemical and biophysical research communications. 2012 ; Vol. 427, No. 2. pp. 280-284.

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abstract = "To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.",

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AU - Mizuno, Hiroya

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AU - Usami, Masaya

AU - Sasaki, Tatsuya

AU - Sato, Hiroshi

AU - Kawahara, Yukio

AU - Hamasaki, Toshimitsu

AU - Nanto, Shinsuke

AU - Hori, Masatsugu

AU - Komuro, Issei

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AB - To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients.

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A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction

Abstract

Keywords

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