A study of inspiratory resistance of dry powder inhaler of agents for asthma control

Shigeaki Suda, Rio Konno, Hajime Kurosawa, Gen Tamura

Research output: Contribution to journalArticle

Abstract

Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control. Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate. Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH2O for Diskus® and Ellipta®, between 35- and 45-cmH20 for Turbuhaler®, and about 60-cmH2O for Twisthaler® were needed. Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.

Original languageEnglish
Pages (from-to)932-936
Number of pages5
JournalJapanese Journal of Allergology
Volume65
Issue number7
Publication statusPublished - 2016

Keywords

  • Agents for asthma control
  • Bronchial asthma
  • Dry powder inhalers
  • Inhalation technique
  • Inspiratory resistance

ASJC Scopus subject areas

  • Immunology and Allergy

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