A study of inspiratory resistance of dry powder inhaler of agents for asthma control

Shigeaki Suda; Rio Konno; Hajime Kurosawa; Gen Tamura

A study of inspiratory resistance of dry powder inhaler of agents for asthma control

Shigeaki Suda, Rio Konno, Hajime Kurosawa, Gen Tamura

Center for Academic Resources and Archives

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control. Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate. Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH₂O for Diskus^® and Ellipta^®, between 35- and 45-cmH₂0 for Turbuhaler^®, and about 60-cmH₂O for Twisthaler^® were needed. Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.

Original language	English
Pages (from-to)	932-936
Number of pages	5
Journal	Japanese Journal of Allergology
Volume	65
Issue number	7
Publication status	Published - 2016

Keywords

Agents for asthma control
Bronchial asthma
Dry powder inhalers
Inhalation technique
Inspiratory resistance

ASJC Scopus subject areas

Immunology and Allergy

Cite this

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title = "A study of inspiratory resistance of dry powder inhaler of agents for asthma control",

abstract = "Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control. Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate. Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH2O for Diskus{\textregistered} and Ellipta{\textregistered}, between 35- and 45-cmH20 for Turbuhaler{\textregistered}, and about 60-cmH2O for Twisthaler{\textregistered} were needed. Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.",

keywords = "Agents for asthma control, Bronchial asthma, Dry powder inhalers, Inhalation technique, Inspiratory resistance",

author = "Shigeaki Suda and Rio Konno and Hajime Kurosawa and Gen Tamura",

year = "2016",

language = "English",

volume = "65",

pages = "932--936",

journal = "Japanese Journal of Allergology",

issn = "0021-4884",

publisher = "Japanese Society of Allergology",

number = "7",

}

TY - JOUR

T1 - A study of inspiratory resistance of dry powder inhaler of agents for asthma control

AU - Suda, Shigeaki

AU - Konno, Rio

AU - Kurosawa, Hajime

AU - Tamura, Gen

PY - 2016

Y1 - 2016

N2 - Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control. Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate. Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH2O for Diskus® and Ellipta®, between 35- and 45-cmH20 for Turbuhaler®, and about 60-cmH2O for Twisthaler® were needed. Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.

AB - Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control. Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate. Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH2O for Diskus® and Ellipta®, between 35- and 45-cmH20 for Turbuhaler®, and about 60-cmH2O for Twisthaler® were needed. Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.

KW - Agents for asthma control

KW - Bronchial asthma

KW - Dry powder inhalers

KW - Inhalation technique

KW - Inspiratory resistance

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SN - 0021-4884

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JO - Japanese Journal of Allergology

JF - Japanese Journal of Allergology

IS - 7

ER -

A study of inspiratory resistance of dry powder inhaler of agents for asthma control

Abstract

Keywords

ASJC Scopus subject areas

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