A study by means of a new assay of the relationship between an outbreak of erythema infectiosum and non-immune hydrops fetalis caused by human parvovirus B19

Nobuo Yaegashi, Kunihiro Okamura, Akira Tsunoda, Masataka Nakamura, Kazuo Sugamura, Akira Yajima

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

An enzyme-linked immunosorbent assay (ELISA), used to detect IgG and IgM antibody specific for human parvovirus B19, was established by use of human parvovirus B19 capsid protein VP-1 Escherichia coli. Paired samples of serum derived from 44 mother and single samples derived from 24 babies having unexplained non-immune hydrops fetalis (NIHF), were tested by means of the assay. Five cases (11%) of NHIF were suspected of having been induced by intrauterine human parvovirus B19 infection because the samples of maternal serum were positive for parvorirus B19 IgM antibody. Four of the five cases arose during an outbreak of erythemia infectiosum. According to our study and previous reports over 90% of NIHF caused by parvovirus B19 intrauterine infection have become clinically overt in the second trimester of pregnancy during a period ranging from 15 to 27 weeks of gestation.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalJournal of Infection
Volume31
Issue number3
DOIs
Publication statusPublished - 1995 Nov

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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