TY - JOUR
T1 - A solitary positive prostate cancer biopsy does not predict a unilateral lesion in radical prostatectomy specimens
AU - Koie, Takuya
AU - Mitsuzuka, Koji
AU - Narita, Shintaro
AU - Yoneyama, Takahiro
AU - Kawamura, Sadafumi
AU - Kaiho, Yasuhiro
AU - Tsuchiya, Norihiko
AU - Tochigi, Tatsuo
AU - Habuchi, Tomonori
AU - Arai, Yoichi
AU - Ohyama, Chikara
N1 - Publisher Copyright:
© 2014 Informa Healthcare.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective. Prostate cancer (PCa) may be a multifocal and bilateral disease. Patients with low-risk PCa and a low number of positive biopsy cores may choose to undergo active surveillance or focal therapy. The aim of this study was to determine the correlation between a solitary positive prostate biopsy core and the pathological outcome after radical prostatectomy (RP). Material and methods. The Michinoku Japan Urological Cancer Study Group database contains data, including preoperative and postoperative information, on 1268 consecutive patients with PCa treated with RP alone at four institutions. This study focused on 151 patients with a single positive biopsy core, preoperative prostate-specific antigen (PSA) level less than 10 ng/ml, biopsy Gleason score less than 8, and clinical stage T1c/T2a/T2b disease. Potential preoperative predictors of unilateral PCa were age, preoperative PSA level, biopsy Gleason score and clinical T stage. Results. The median age and preoperative PSA level were 65 years (range 47-76 years) and 6.00 ng/ml (range 0.50-9.80 ng/ml), respectively. Unilateral PCa was identified in 41% of the patients. Extraprostatic extension or seminal vesicle invasion was observed in 26% of all patients. Conclusion. Serum PSA levels were significantly higher in the bilateral PCa group than in the unilateral PCa group in the current study. For patients with PCa having a solitary positive prostate biopsy core, definitive therapy such as RP should be considered.
AB - Objective. Prostate cancer (PCa) may be a multifocal and bilateral disease. Patients with low-risk PCa and a low number of positive biopsy cores may choose to undergo active surveillance or focal therapy. The aim of this study was to determine the correlation between a solitary positive prostate biopsy core and the pathological outcome after radical prostatectomy (RP). Material and methods. The Michinoku Japan Urological Cancer Study Group database contains data, including preoperative and postoperative information, on 1268 consecutive patients with PCa treated with RP alone at four institutions. This study focused on 151 patients with a single positive biopsy core, preoperative prostate-specific antigen (PSA) level less than 10 ng/ml, biopsy Gleason score less than 8, and clinical stage T1c/T2a/T2b disease. Potential preoperative predictors of unilateral PCa were age, preoperative PSA level, biopsy Gleason score and clinical T stage. Results. The median age and preoperative PSA level were 65 years (range 47-76 years) and 6.00 ng/ml (range 0.50-9.80 ng/ml), respectively. Unilateral PCa was identified in 41% of the patients. Extraprostatic extension or seminal vesicle invasion was observed in 26% of all patients. Conclusion. Serum PSA levels were significantly higher in the bilateral PCa group than in the unilateral PCa group in the current study. For patients with PCa having a solitary positive prostate biopsy core, definitive therapy such as RP should be considered.
KW - Needle biopsy
KW - Pathological tumor stage
KW - Prostate cancer
KW - Radical prostatectomy
KW - Single positive core
KW - Tumor volume
UR - http://www.scopus.com/inward/record.url?scp=84924963230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924963230&partnerID=8YFLogxK
U2 - 10.3109/21681805.2014.951959
DO - 10.3109/21681805.2014.951959
M3 - Article
C2 - 25165894
AN - SCOPUS:84924963230
VL - 49
SP - 103
EP - 107
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
SN - 2168-1805
IS - 2
ER -