A small amount of tetrachloroethylene ingestion from drinking water accelerates antigen-stimulated allergic responses

Makoto Seo, Takeo Yamagiwa, Ryo Kobayashi, Koji Ikeda, Masahiko Satoh, Naoki Inagaki, Hiroichi Nagai, Hisamitsu Nagase

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Previously, we observed that tetrachloroethylene (perchloroethylene, PCE) increased histamine release and inflammatory mediator production from antigen-stimulated mast cells. In this study, we examined the enhancing effect of low concentrations of PCE in drinking water on antigen-stimulated allergic responses. After exposure of Wistar rats to PCE in drinking water for 2 or 4 weeks, we performed a passive cutaneous anaphylaxis (PCA) reaction. PCE exposure for 4 weeks enhanced PCA reaction in a dose-dependent manner. In pathological studies, PCE exposure for 2 weeks exacerbated inflammation characterized by infiltration of lymphocytes and accumulation of mast cells around the vessel. Non-purified mast cells (NPMCs) from rats treated with 1 mg/L PCE in drinking water for 2 weeks increased antigen-stimulated histamine release. Furthermore, the leukocytes of rats treated with PCE in drinking water for 4 weeks showed increased interleukin (IL)-4 expression. The mechanism of enhancing the PCA reaction is assumed to be that PCE increases IL-4 production and PCE causes T helper (Th) 1/Th2-type helper T-cell imbalance and increases histamine release from excessively accumulated mast cells. The results suggest that the intake of PCE in drinking water, even at a low concentration, leads to the initiation and acceleration of allergic diseases.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalImmunobiology
Volume213
Issue number8
DOIs
Publication statusPublished - 2008 Oct 6
Externally publishedYes

Keywords

  • Allergy
  • IL-4
  • Mast cells
  • Tetrachloroethylene
  • Th1/Th2-type helper T-cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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