A simple method for measurement of cerebral blood flow using 123I-IMP SPECT with calibrated standard input function by one point blood sampling; validation of calibration by one point venous blood sampling as a substitute for arterial blood sampling

H. Ito, T. Akaizawa, Ryoui Goto, M. Koyama, R. Kawashima, S. Ono, S. Yoshioka, K. Ishii, T. Kinoshita, Y. Inukai, S. Abe, H. Atsumi, M. Sato, H. Fukuda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In a simplified method for measurement of cerebral blood flow using one 123I-IMP SPECT scan and one point arterial blood sampling (Autoradiography method), input function is obtained by calibrating a standard input function by one point arterial blood sampling. A purpose of this study is validation of calibration by one point venous blood sampling as a substitute for one point arterial blood sampling. After intravenous infusion of 123I-IMP, frequent arterial and venous blood sampling were simultaneously performed on 12 patients of CNS disease without any heart and lung disease and 5 normal volunteers. The radioactivity ratio of venous whole blood which obtained from cutaneous cubital vein to arterial whole blood were 0.76 ± 0.08, 0.80 ± 0.05, 0.81 ± 0.06, 0.83 ± 0.11 at 10, 20, 30, 50 min after 123I-IMP infusion, respectively. The venous blood radio activities were always 20% lower than those of arterial blood radioactivity during 50 min. However, the ratio which obtained from cutaneous dorsal hand vein to artery were 0.93 ± 0.02, 0.94 ± 0.05, 0.98 ± 0.04, 0.98 ± 0.03, at 10, 20, 30, 50 min after 123I-IMP infusion, respectively. The venous blood radioactivity was consistent with artery. These indicate that arterio-venous difference of radioactivity in a peripheral cutaneous vein like a dorsal hand vein is minimal due to arterio-venous shunt in palm. Therefore, a substitution by blood sampling from cutaneous dorsal hand vein for artery will be possible. Optimized time for venous blood sampling evaluated by error analysis was 20 min after 123I-IMP infusion, which is 10 min later than that of arterial blood sampling.

Original languageEnglish
Pages (from-to)1071-1076
Number of pages6
JournalKakuigaku
Volume31
Issue number9
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • I-IMP
  • SPECT
  • autoradiography method
  • regional CBF
  • venous blood sampling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'A simple method for measurement of cerebral blood flow using <sup>123</sup>I-IMP SPECT with calibrated standard input function by one point blood sampling; validation of calibration by one point venous blood sampling as a substitute for arterial blood sampling'. Together they form a unique fingerprint.

Cite this