A simple and early prognostic index for acute renal failure patients requiring renal replacement therapy

Shigekazu Yuasa, Norihiro Takahashi, Tetsuo Shoji, Koichi Uchida, Hideyasu Kiyomoto, Mayuko Hashimoto, Hiroshi Fujioka, Yoko Fujita, Hirofumi Hitomi, Hirohide Matsuo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Recent advances in technology have not substantially changed the high mortality rate associated with acute renal failure (ARF). To obtain a simple, valid prognostic index, we retrospectively evaluated the relative importance of demographic data, causes (acute insults) of renal failure, and comorbid clinical conditions for the outcome in 102 ARF patients who received renal replacement therapy with an overall mortality rate of 65% (66 of 102). There were no significant differences between survivors and nonsurvivors in age and gender. Mortality according to acute insults was similar to that of the whole population studied. Of the 10 clinical conditions at the time of the first renal replacement therapy, mechanical ventilation (p = 0.0002), cardiac failure (p = 0.0006), hepatic failure (p = 0.003), central nervous system dysfunction (p = 0.005), and oliguria (p = 0.04) were found to be significantly related to mortality by univariate analysis. Furthermore, multivariate analysis demonstrated that only mechanical ventilation, cardiac failure, and hepatic failure were significant risk factors. Survival was directly related to the number of significant variables in univariate analysis: zero, 89% (8 of 9); one, 62% (21 of 34); two, 19% (5 of 27); three, 10% (2 of 20); four, 0% (0 of 8); five, 0% (0 of 4). This simple and early prognostic index, derived from the assessment of clinical conditions which were easily determined at the patient's bedside, could be useful for outcome prediction in ARF patients requiring renal replacement therapy.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalArtificial Organs
Issue number4
Publication statusPublished - 1998
Externally publishedYes


  • Acute renal failure
  • Prognosis
  • Renal replacement therapy

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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