@article{69bf94cdb1484a82a5f091f6d60fa248,
title = "A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents",
abstract = "We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.",
keywords = "BCG, CD4, LTBI, T cell antigen, Tuberculosis, Vaccine",
author = "Chelsea Carpenter and John Sidney and Ravi Kolla and Kaustuv Nayak and Helena Tomiyama and Claudia Tomiyama and Padilla, {Oscar A.} and Virginie Rozot and Ahamed, {Syed F.} and Carlos Ponte and Valeria Rolla and Antas, {Paulo R.} and Anmol Chandele and John Kenneth and Seetha Laxmi and Edward Makgotlho and Valentina Vanini and Giuseppe Ippolito and Kazanova, {Alexandra S.} and Panteleev, {Alexander V.} and Willem Hanekom and Harriet Mayanja-Kizza and David Lewinsohn and Mayuko Saito and McElrath, {M. Juliana} and Boom, {W. Henry} and Delia Goletti and Robert Gilman and Lyadova, {Irina V.} and Scriba, {Thomas J.} and Kallas, {Esper G.} and Kaja Murali-Krishna and Alessandro Sette and {Lindestam Arlehamn}, {Cecilia S.}",
note = "Funding Information: This work was supported by the National Institutes of Health [contract HHSN272200900044C to A.S., contract HHSN266200700022C/NO1-AI-70022 to W.H.B, grant R37AI052731 to E.G.K]: the IOC/FIOCRUZ [CNPq research fellowship PQ-2-Brazil to P.R.A.]: The Italian Ministry of Health [Ricerca Corrente to D.G.], the Bill and Melinda Gates Foundation [ OPP1066265 to T.J.S.], and the HIV Vaccine Trials Network [RAMP scholarship to O.A.P.], the Russian Science Foundation [ 15-15-00136 to I.V.L.]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.tube.2015.07.001",
language = "English",
volume = "95",
pages = "713--721",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Churchill Livingstone",
number = "6",
}