A semi-automated synthesis system for routine preparation of [11C]YM-09151-2 and [11C]pyrilamine from [11C]methyl iodide

Ren Iwata, Kentaro Hatano, Kazuhiko Yanai, Toshihiro Takahashi, Kiichi Ishiwata, Tatsuo Ido

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A synthesis system has been developed for routine preparation of the 11C-labeled receptor ligands, [11C]YM-09151-2 and [11C]pyrilamine, from [11C]methyl iodide produced automatically. The system features semi-automated operation, from the reaction of the desmethyl derivative with [11C]methyl iodide to filtration with a specifically developed syringe pump of the final product in saline into a sterile vial. The preparations were completed within 45 min after irradiation and approx. 1 GBq (27 mCi) of [11C]YM-09151-2 or [11C]pyrilamine was obtained with a radiochemical and chemical purity of >99% and an average specific activity of 44 GBq/μmol (1.2 Ci/μmol) at the end of synthesis. Sterile and pyrogen-free 11C-labeled receptor ligands suitable for human injection are routinely prepared using the present synthesis system.

Original languageEnglish
Pages (from-to)202-205
Number of pages4
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume42
Issue number2
DOIs
Publication statusPublished - 1991 Jan 1

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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