Abstract
Orally active converting enzyme inhibitor (Captopril, SQ 14225) was administered in a dose of 50 mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II) and 8 renovascular hypertensive patients (Group III). In Group III, 5 of 8 patients had control plasma renin activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of Captopril was greater in 7 of 8 patients than that in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renal aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.
Original language | English |
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Pages (from-to) | 311-312 |
Number of pages | 2 |
Journal | the tohoku journal of experimental medicine |
Volume | 131 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1980 |
Keywords
- Captopril
- renin
- renovascular hypertension
- screening test
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)