TY - JOUR
T1 - A Role of Peripheral Leukocytes in Vascular Permeability and Edema Formation in Air Pouch Type Allergic Inflammation in Rats
AU - Omata, Mitugu
AU - Watanabe, Masako
AU - Hirasawa, Noriyasu
AU - Tsurufuji, Susumu
AU - Mue, Suetsugu
AU - Ohuchi, Kazuo
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/12
Y1 - 1991/12
N2 - Using an air pouch type allergic inflammation model in rats, a role of circulating leukocytes in allergic inflammation responses was investigated by comparing normal rats with peripheral leu-kocytopenia rats induced by cyclophosphamide treatment. In the leukocytopenia rats, vascular permeability, edema formation, leukocyte infiltration into the pouch fluid, neutrophil chemotactic activity in the pouch fluid occurred both at the early phase (4 h) and the late phase (8 h) after the antigen challenge were decreased. However, edema formation induced by intradermal injection of arachidonate metabolites, serotonin, or platelet activating factor was not suppressed at all in the leukocytopenia rats. A possible role of peripheral leukocytes in allergic and non-allergic inflammation is discussed.
AB - Using an air pouch type allergic inflammation model in rats, a role of circulating leukocytes in allergic inflammation responses was investigated by comparing normal rats with peripheral leu-kocytopenia rats induced by cyclophosphamide treatment. In the leukocytopenia rats, vascular permeability, edema formation, leukocyte infiltration into the pouch fluid, neutrophil chemotactic activity in the pouch fluid occurred both at the early phase (4 h) and the late phase (8 h) after the antigen challenge were decreased. However, edema formation induced by intradermal injection of arachidonate metabolites, serotonin, or platelet activating factor was not suppressed at all in the leukocytopenia rats. A possible role of peripheral leukocytes in allergic and non-allergic inflammation is discussed.
KW - Boyden chamber
KW - air pouch
KW - allergic inflammation
KW - chemotactic activity
KW - cyclophosphamide
KW - edema formation
KW - leukocyte infiltration
KW - leukocytopenia
KW - pouch fluid
KW - vascular permeability
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U2 - 10.1248/bpb1978.14.267
DO - 10.1248/bpb1978.14.267
M3 - Article
C2 - 1770431
AN - SCOPUS:0025915881
VL - 14
SP - 267
EP - 275
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -