A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area

Eishichi Miyamoto, Kohji Fukunaga

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+-influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+-dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalNeuroscience Research
Volume24
Issue number2
DOIs
Publication statusPublished - 1996 Jan

Keywords

  • CA1 pyramidal cells
  • Ca-influx
  • CaM kinase II
  • Glutamate receptor
  • Hippocampus
  • Long-term potentiation
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)

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