Abstract
Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+-influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+-dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.
Original language | English |
---|---|
Pages (from-to) | 117-122 |
Number of pages | 6 |
Journal | Neuroscience Research |
Volume | 24 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1996 Jan |
Externally published | Yes |
Keywords
- CA1 pyramidal cells
- Ca-influx
- CaM kinase II
- Glutamate receptor
- Hippocampus
- Long-term potentiation
- NMDA
ASJC Scopus subject areas
- Neuroscience(all)