A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

Onn Brandman; Jacob Stewart-Ornstein; Daisy Wong; Adam Larson; Christopher C. Williams; Gene Wei Li; Sharleen Zhou; David King; Peter S. Shen; Jimena Weibezahn; Joshua G. Dunn; Silvi Rouskin; Toshifumi Inada; Adam Frost; Jonathan S. Weissman

doi:10.1016/j.cell.2012.10.044

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

Onn Brandman, Jacob Stewart-Ornstein, Daisy Wong, Adam Larson, Christopher C. Williams, Gene Wei Li, Sharleen Zhou, David King, Peter S. Shen, Jimena Weibezahn, Joshua G. Dunn, Silvi Rouskin, Toshifumi Inada, Adam Frost, Jonathan S. Weissman

Research output: Contribution to journal › Article › peer-review

381 Citations (Scopus)

Abstract

A ribosome-bound complex designated RQC associates with 60S ribosomal subunits containing stalled polypeptides to trigger their degradation.

Original language	English
Pages (from-to)	1042-1054
Number of pages	13
Journal	Cell
Volume	151
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2012.10.044
Publication status	Published - 2012 Nov 21
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2012.10.044

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Brandman, O., Stewart-Ornstein, J., Wong, D., Larson, A., Williams, C. C., Li, G. W., Zhou, S., King, D., Shen, P. S., Weibezahn, J., Dunn, J. G., Rouskin, S., Inada, T., Frost, A., & Weissman, J. S. (2012). A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress. Cell, 151(5), 1042-1054. https://doi.org/10.1016/j.cell.2012.10.044

Brandman, O, Stewart-Ornstein, J, Wong, D, Larson, A, Williams, CC, Li, GW, Zhou, S, King, D, Shen, PS, Weibezahn, J, Dunn, JG, Rouskin, S, Inada, T, Frost, A & Weissman, JS 2012, 'A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress', Cell, vol. 151, no. 5, pp. 1042-1054. https://doi.org/10.1016/j.cell.2012.10.044

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abstract = "A ribosome-bound complex designated RQC associates with 60S ribosomal subunits containing stalled polypeptides to trigger their degradation.",

author = "Onn Brandman and Jacob Stewart-Ornstein and Daisy Wong and Adam Larson and Williams, {Christopher C.} and Li, {Gene Wei} and Sharleen Zhou and David King and Shen, {Peter S.} and Jimena Weibezahn and Dunn, {Joshua G.} and Silvi Rouskin and Toshifumi Inada and Adam Frost and Weissman, {Jonathan S.}",

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AU - Li, Gene Wei

AU - Zhou, Sharleen

AU - King, David

AU - Shen, Peter S.

AU - Weibezahn, Jimena

AU - Dunn, Joshua G.

AU - Rouskin, Silvi

AU - Inada, Toshifumi

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A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

Abstract

ASJC Scopus subject areas

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