@article{ee866a900b434acbbf1885a5825f926b,
title = "A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress",
abstract = "A ribosome-bound complex designated RQC associates with 60S ribosomal subunits containing stalled polypeptides to trigger their degradation.",
author = "Onn Brandman and Jacob Stewart-Ornstein and Daisy Wong and Adam Larson and Williams, {Christopher C.} and Li, {Gene Wei} and Sharleen Zhou and David King and Shen, {Peter S.} and Jimena Weibezahn and Dunn, {Joshua G.} and Silvi Rouskin and Toshifumi Inada and Adam Frost and Weissman, {Jonathan S.}",
note = "Funding Information: We thank the members of the Weissman lab, M. Bassik, E. Boydston, L. Gilbert, A. Grenninger, C. Jan, M. Jonikas, M. Kampmann, Y. Liu, W. Luddington, M. McKeon, E. Oh, C. Reiger, M. Smith, N. Stern-Ginossar, and P. Walter for their valuable help with the manuscript and input on the project; T. Becker and R. Beckmann for help with EM; M. Larson and B. Toyama for help with graphic design; and M. Szeto for help in creating the fluorescent reporters. O.B. was supported by a Helen Hay Whitney postdoctoral fellowship. This work was funded by the Howard Hughes Medical Institute (to J.S.W.). Publisher Copyright: {\textcopyright} 2012 Elsevier Inc.",
year = "2012",
month = nov,
day = "21",
doi = "10.1016/j.cell.2012.10.044",
language = "English",
volume = "151",
pages = "1042--1054",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}