A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

Onn Brandman, Jacob Stewart-Ornstein, Daisy Wong, Adam Larson, Christopher C. Williams, Gene Wei Li, Sharleen Zhou, David King, Peter S. Shen, Jimena Weibezahn, Joshua G. Dunn, Silvi Rouskin, Toshifumi Inada, Adam Frost, Jonathan S. Weissman

Research output: Contribution to journalArticlepeer-review

317 Citations (Scopus)

Abstract

A ribosome-bound complex designated RQC associates with 60S ribosomal subunits containing stalled polypeptides to trigger their degradation.

Original languageEnglish
Pages (from-to)1042-1054
Number of pages13
JournalCell
Volume151
Issue number5
DOIs
Publication statusPublished - 2012 Nov 21

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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