A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL- 6 gene rearrangement in B-cell diffuse large cell lymphoma

Ryo Ichinohasama; Ikuo Miura; Tadao Funato; Isao Sato; Chiyuki Suzuki; Yoshiko Saito; John F. Decoteau; Jerome B. Myers; Marshall E. Kadin; Takashi Sawai; Kiyoshi Ooya

doi:10.1016/S0165-4608(97)00412-3

A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL- 6 gene rearrangement in B-cell diffuse large cell lymphoma

Ryo Ichinohasama, Ikuo Miura, Tadao Funato, Isao Sato, Chiyuki Suzuki, Yoshiko Saito, John F. Decoteau, Jerome B. Myers, Marshall E. Kadin, Takashi Sawai, Kiyoshi Ooya

University Hospital (not affiliated with any section)

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Two cases of B-cell diffuse large cell lymphoma associated with the t(3;7)(q27;p12) and BCL-6 rearrangement are described. Cytogenetic studies revealed [case 1] 47,XY,t(3;7)(q27;p12),+12 and [case 2] 45,X,- Y,t(3;7)(q27;p12),del(6)(q21q25),+16,-21. The translocation of each case had a non-random chromosomal change involving a 3q27 locus associated with BCL-6 gene rearrangement identified by Southern blot analysis. Both cases involved multiple lymph nodes and extranodal regions, such as stomach and peritoneal cavity in case 1, extranodal retroperitoneal space, subcutis, probable liver, and colon in case 2. Chemotherapy provided only short survival after onset: 17 and 16 months, respectively. Altered expression of adhesion molecules CD44, CD54 (case 1) and CD11a and CD18 (case 2) may help to explain the poor outcome of these patients.

Original language	English
Pages (from-to)	19-27
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(97)00412-3
Publication status	Published - 1998 Jul

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-4608(97)00412-3

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Ichinohasama, R., Miura, I., Funato, T., Sato, I., Suzuki, C., Saito, Y., Decoteau, J. F., Myers, J. B., Kadin, M. E., Sawai, T., & Ooya, K. (1998). A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL- 6 gene rearrangement in B-cell diffuse large cell lymphoma. Cancer Genetics and Cytogenetics, 104(1), 19-27. https://doi.org/10.1016/S0165-4608(97)00412-3

Ichinohasama, R, Miura, I, Funato, T, Sato, I, Suzuki, C, Saito, Y, Decoteau, JF, Myers, JB, Kadin, ME, Sawai, T & Ooya, K 1998, 'A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL- 6 gene rearrangement in B-cell diffuse large cell lymphoma', Cancer Genetics and Cytogenetics, vol. 104, no. 1, pp. 19-27. https://doi.org/10.1016/S0165-4608(97)00412-3

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abstract = "Two cases of B-cell diffuse large cell lymphoma associated with the t(3;7)(q27;p12) and BCL-6 rearrangement are described. Cytogenetic studies revealed [case 1] 47,XY,t(3;7)(q27;p12),+12 and [case 2] 45,X,- Y,t(3;7)(q27;p12),del(6)(q21q25),+16,-21. The translocation of each case had a non-random chromosomal change involving a 3q27 locus associated with BCL-6 gene rearrangement identified by Southern blot analysis. Both cases involved multiple lymph nodes and extranodal regions, such as stomach and peritoneal cavity in case 1, extranodal retroperitoneal space, subcutis, probable liver, and colon in case 2. Chemotherapy provided only short survival after onset: 17 and 16 months, respectively. Altered expression of adhesion molecules CD44, CD54 (case 1) and CD11a and CD18 (case 2) may help to explain the poor outcome of these patients.",

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AU - Decoteau, John F.

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AB - Two cases of B-cell diffuse large cell lymphoma associated with the t(3;7)(q27;p12) and BCL-6 rearrangement are described. Cytogenetic studies revealed [case 1] 47,XY,t(3;7)(q27;p12),+12 and [case 2] 45,X,- Y,t(3;7)(q27;p12),del(6)(q21q25),+16,-21. The translocation of each case had a non-random chromosomal change involving a 3q27 locus associated with BCL-6 gene rearrangement identified by Southern blot analysis. Both cases involved multiple lymph nodes and extranodal regions, such as stomach and peritoneal cavity in case 1, extranodal retroperitoneal space, subcutis, probable liver, and colon in case 2. Chemotherapy provided only short survival after onset: 17 and 16 months, respectively. Altered expression of adhesion molecules CD44, CD54 (case 1) and CD11a and CD18 (case 2) may help to explain the poor outcome of these patients.

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A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL- 6 gene rearrangement in B-cell diffuse large cell lymphoma

Abstract

ASJC Scopus subject areas

UN SDGs

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