TY - JOUR
T1 - A realistic simulation of saccular cerebral aneurysm formation
T2 - Focussing on a novel haemodynamic index, the gradient oscillatory number
AU - Shimogonya, Y.
AU - Ishikawa, T.
AU - Imai, Y.
AU - Matsuki, N.
AU - Yamaguchi, T.
N1 - Funding Information:
The authors thank the VISC07 committee and Dr. Makoto Ohta of the Institute of Fluid Science, Tohoku University, for providing the arterial geometry data through the VISC07 project. This research was supported by a Research Fellowship for Young Scientists from the Japan Society for the Promotion of Science (JSPS) No. 1955081, a Grant-in-Aid for Scientific Research (S) from JSPS No. 19100008 ‘Computational Nanobiomechanics for the diagnosis, treatment, and prevention of diseases of blood, circulatory, and digestive organs,’ the 2007 Global COE Program ‘Global Nano-Biomedical Engineering Education and Research Network Centre,’ and Research and Development of the Next-Generation Integrated Simulation of Living Matter, a part of the Development and use of the Next-generation Supercomputer Project of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
PY - 2009/9
Y1 - 2009/9
N2 - Although how cerebral aneurysms initiate and grow is still unclear, haemodynamics is thought to play an important role. In order to better understand the aneurysm formation mechanism, we performed a computational analysis of aneurysm formation for a patient-specific arterial geometry. First, CFD was used to perform a pulsatile blood flow analysis and calculate a novel haemodynamic index, the gradient oscillatory number (GON). Then, using aneurysm growth model in which the proliferation of the wall was hypothesised, we performed an aneurysm formation analysis based on the GON index distribution. The result showed that a saccular cerebral aneurysm could appear based on our hypothesis for a patient-specific arterial geometry. On the other hand, a saccular aneurysm was not observed when assuming only strength degradation of the wall. Our findings have suggested that an arterial biological process, such as the proliferation of the wall, may play a vital role in saccular aneurysm formation.
AB - Although how cerebral aneurysms initiate and grow is still unclear, haemodynamics is thought to play an important role. In order to better understand the aneurysm formation mechanism, we performed a computational analysis of aneurysm formation for a patient-specific arterial geometry. First, CFD was used to perform a pulsatile blood flow analysis and calculate a novel haemodynamic index, the gradient oscillatory number (GON). Then, using aneurysm growth model in which the proliferation of the wall was hypothesised, we performed an aneurysm formation analysis based on the GON index distribution. The result showed that a saccular cerebral aneurysm could appear based on our hypothesis for a patient-specific arterial geometry. On the other hand, a saccular aneurysm was not observed when assuming only strength degradation of the wall. Our findings have suggested that an arterial biological process, such as the proliferation of the wall, may play a vital role in saccular aneurysm formation.
KW - Gradient oscillatory number
KW - Growth
KW - Haemodynamics
KW - Patient-specific geometry
KW - Saccular cerebral aneurysm
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U2 - 10.1080/10618560902953575
DO - 10.1080/10618560902953575
M3 - Article
AN - SCOPUS:70449086090
VL - 23
SP - 583
EP - 593
JO - International Journal of Computational Fluid Dynamics
JF - International Journal of Computational Fluid Dynamics
SN - 1061-8562
IS - 8
ER -