A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Yuji Takano; Takashi Yokawa; Asami Masuda; Jun Niimi; Satoshi Tanaka; Naoyuki Hironaka

doi:10.1016/j.neulet.2011.01.004

A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Yuji Takano, Takashi Yokawa, Asami Masuda, Jun Niimi, Satoshi Tanaka, Naoyuki Hironaka

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10. min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	Neuroscience Letters
Volume	491
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.01.004
Publication status	Published - 2011 Mar 10
Externally published	Yes

Keywords

Animal model
FMRI
Frontal cortex
Nucleus accumbens
Rat
TDCS

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2011.01.004

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title = "A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI",

abstract = "Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10. min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.",

keywords = "Animal model, FMRI, Frontal cortex, Nucleus accumbens, Rat, TDCS",

author = "Yuji Takano and Takashi Yokawa and Asami Masuda and Jun Niimi and Satoshi Tanaka and Naoyuki Hironaka",

note = "Funding Information: This work was supported by the SHIMOJO Implicit Brain Function Project , ERATO , JST . We are grateful to Dr. Shinsuke Shimojo (California Institute of Technology) and Dr. Katsumi Watanabe (Tokyo University) for their very valuable suggestions.",

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doi = "10.1016/j.neulet.2011.01.004",

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AU - Takano, Yuji

AU - Yokawa, Takashi

AU - Masuda, Asami

AU - Niimi, Jun

AU - Tanaka, Satoshi

AU - Hironaka, Naoyuki

N1 - Funding Information: This work was supported by the SHIMOJO Implicit Brain Function Project , ERATO , JST . We are grateful to Dr. Shinsuke Shimojo (California Institute of Technology) and Dr. Katsumi Watanabe (Tokyo University) for their very valuable suggestions.

PY - 2011/3/10

Y1 - 2011/3/10

N2 - Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10. min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.

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KW - Animal model

KW - FMRI

KW - Frontal cortex

KW - Nucleus accumbens

KW - Rat

KW - TDCS

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A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Abstract

Keywords

ASJC Scopus subject areas

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