A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Yuji Takano, Takashi Yokawa, Asami Masuda, Jun Niimi, Satoshi Tanaka, Naoyuki Hironaka

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10. min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalNeuroscience Letters
Volume491
Issue number1
DOIs
Publication statusPublished - 2011 Mar 10
Externally publishedYes

Keywords

  • Animal model
  • FMRI
  • Frontal cortex
  • Nucleus accumbens
  • Rat
  • TDCS

ASJC Scopus subject areas

  • Neuroscience(all)

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