A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Yuji Takano; Takashi Yokawa; Asami Masuda; Jun Niimi; Satoshi Tanaka; Naoyuki Hironaka

doi:10.1016/j.neulet.2011.01.004

A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Yuji Takano, Takashi Yokawa, Asami Masuda, Jun Niimi, Satoshi Tanaka, Naoyuki Hironaka

Research output: Contribution to journal › Article

43 Citations (Scopus)

Abstract

Transcranial direct current stimulation (tDCS) is one of the noteworthy noninvasive brain stimulation techniques, but the mechanism of its action remains unclear. With the aim of clarifying the mechanism, we developed a rat model and measured its effectiveness using fMRI. Carbon fiber electrodes were placed on the top of the head over the frontal cortex as the anode and on the neck as the cathode. The stimulus was 400- or 40-μA current applied for 10. min after a baseline recording under an anesthetized condition. The 400-μA stimulation significantly increased signal intensities in the frontal cortex and nucleus accumbens. This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	Neuroscience Letters
Volume	491
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.01.004
Publication status	Published - 2011 Mar 10
Externally published	Yes

Keywords

Animal model
FMRI
Frontal cortex
Nucleus accumbens
Rat
TDCS

ASJC Scopus subject areas

Neuroscience(all)

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Takano, Y., Yokawa, T., Masuda, A., Niimi, J., Tanaka, S., & Hironaka, N. (2011). A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI. Neuroscience Letters, 491(1), 40-43. https://doi.org/10.1016/j.neulet.2011.01.004

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