A rare case of ACTH-independent macronodular adrenal hyperplasia associated with aldosterone-producing adenoma

Eri Hayakawa, Takanobu Yoshimoto, Kiichiro Hiraishi, Masako Kato, Hajime Izumiyama, Hironobu Sasano, Yukio Hirata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 52-year-old man was evaluated for incidentally discovered bilateral adrenal masses. He had drugresistant hypertension but lacked Cushingoid features. Endocrinological tests revealed autonomous secretion of cortisol and aldosterone with suppressed plasma ACTH and renin activity. A selective adrenal venous sampling demonstrated aldosterone hypersecretion from the left adrenal vein. The clinical diagnosis of subclinical Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) associated with primary aldosteronism was made, and he underwent left adrenalectomy; the resected adrenal lesion was consistent with the pathological diagnosis of AIMAH coexistent with aldosterone-producing adenoma (APA). This is a very rare case of AIMAH with concomitant unilateral APA, whose hypertension improved after surgery.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalInternal Medicine
Volume50
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • ACTH-independent macronodular adrenal hyperplasia
  • Adrenal venous sampling
  • Primary aldosteronism
  • Subclinical cushing's syndrome

ASJC Scopus subject areas

  • Internal Medicine

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