A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada, Ren Iwata, Hiroshi Sugiyama, Kazunori Sato, Claudio Pascali, Hiroshi Fukuda, Kazuo Kubota, Roko Kubota, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

    Original languageEnglish
    Pages (from-to)601-606
    Number of pages6
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume33
    Issue number7
    DOIs
    Publication statusPublished - 1993 Jul

    Keywords

    • N‐[F]fluoroacetyl‐5‐methoxytryptamine
    • N‐fluoroacetyl‐5‐methoxytryptamine
    • [F]fluoride
    • [fluoroacetyl‐F]Fluoromelatonin
    • ethyl bromoacetate
    • ethyl p‐toluensulfonyloxyacetate

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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  • Cite this

    Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606. https://doi.org/10.1002/jlcr.2580330706