A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Kazuo Kubota, Takehiko Fujiwara, Hiroshi Sugiyama, Yoshinao Abe, Tachio Sato, Taiju Matsuzawa, Hiromu Takahashi, Akira Wakui, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

    Original languageEnglish
    Pages (from-to)847-854
    Number of pages8
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Issue number7
    Publication statusPublished - 1990 Jan 1

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry


    Dive into the research topics of 'A rapid and efficient synthesis of 2‐deoxy‐2‐[<sup>18</sup>F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose'. Together they form a unique fingerprint.

    Cite this