A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Kazuo Kubota, Takehiko Fujiwara, Hiroshi Sugiyama, Yoshinao Abe, Tachio Sato, Taiju Matsuzawa, Hiromu Takahashi, Akira Wakui, Tatsuo Ido

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    4 Citations (Scopus)

    Abstract

    Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

    Original languageEnglish
    Pages (from-to)847-854
    Number of pages8
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume28
    Issue number7
    DOIs
    Publication statusPublished - 1990 Jan 1

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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