A randomized trial of postoperative UFT therapy in p stage I, II non-small cell lung cancer: North-east Japan Study Group for Lung Cancer Surgery

Chiaki Endo, Yasuki Saito, Hiroshi Iwanami, Takao Tsushima, Tadashi Imai, Mitsuo Kawamura, Takashi Kondo, Kaoru Koike, Masashi Handa, Ryuzo Kanno, Shigefumi Fujimura

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Objective: A prospective randomized trial was performed to investigate the prognostic advantage of postoperative adjuvant chemotherapy in patients with resected stage I-II non-small cell lung cancer (NSCLC). Patients and methods: From March 1992 to December 1994, 221 patients with completely resected stage I-II primary NSCLC were enrolled and randomly assigned to two groups, as follows: 2-year oral administration of Uracil plus Tegafur (UFT) (adjuvant group, 109 patients), and surgical treatment alone (control group, 110 patients). Results: The overall 5-year survival rates were 79% for the adjuvant group and 75% for the control group, and there was no statistical significance. The 5-year disease-free survival rates were 78% for the adjuvant group and 71% for the control group, and there was also no statistical significance. There have been seen no severe complications in the adjuvant group. The mean total dosages of UFT were about 75% of maximum basic amount. Conclusions: The UFT regimen was feasible. However, we have not observed any survival benefit in the adjuvant group. Larger trials are needed to confirm the effect of UFT to patients with resected NSCLC.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalLung Cancer
Volume40
Issue number2
DOIs
Publication statusPublished - 2003 May 1
Externally publishedYes

Keywords

  • Adjuvant chemotherapy
  • Five-year survival
  • Non-small cell lung cancer
  • Prognosis
  • Randomized controlled trial
  • Stage I-II
  • UFT

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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