A randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab vs dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent or persistent cervical carcinoma: Japan Clinical Oncology Group Study (JCOG1311)

Mitsuya Ishikawa, Kenichi Nakamura, Taro Shibata, Kiyo Tanaka, Ryo Kitagawa, Hiroaki Kobayashi, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A randomized controlled trial has been initiated to compare chemotherapy containing dose-dense paclitaxel plus carboplatin with or without bevacizumab to a conventional regimen containing tri-weekly paclitaxel plus carboplatin with or without bevacizumab. Eligible patients are those with stage IVB, recurrent or persistent cervical carcinoma not amenable to curative treatment with local therapy. Patients are randomly assigned to either the conventional or dose-dense regimen. However, patients who are at increased risk of adverse events following bevacizumab administration will not receive this drug. The primary endpoint of phase II part is response rate. If the response rate of the dose-dense regimen is better than that of conventional regimen, this study will proceed to phase III, where the primary endpoint is overall survival. Secondary endpoints in phase III part are progression-free survival, response rates, adverse events, serious adverse events and the proportion of non-hospitalization periods compared with planned treatment periods.

Original languageEnglish
Pages (from-to)1096-1100
Number of pages5
JournalJapanese journal of clinical oncology
Volume48
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

Keywords

  • bevacizumab
  • carboplatin
  • chemotherapy
  • metastatic or recurrent cervical carcinoma
  • paclitaxel
  • randomized controlled trial
  • survival

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'A randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab vs dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent or persistent cervical carcinoma: Japan Clinical Oncology Group Study (JCOG1311)'. Together they form a unique fingerprint.

Cite this