A protein/antibiotic releasing poly(lactic-co-glycolic acid)/lecithin scaffold for bone repair applications

Xuetao Shi, Yingjun Wang, Li Ren, Wei Huang, Dong An Wang

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    Novel poly(lactic-co-glycolic acid) (PLGA)-hybridizing-lecithin scaffolds loaded with drug or protein were prepared with water/oil/water techniques and sintering microspheres technique. In such fabricated composite scaffolds (abbreviated "PLGA/Lec-SMS"), the introduction of lecithin component has been proven capable of largely enhancing Gentamicin (GS) and protein (Bovine Serum Albumin) encapsulation efficiency. The in vitro GS and BSA releasing profiles of PLGA/Lec-SMS system were plotted basing over 60 days' and 18 days' data collection, respectively. It indicates a sustained releasing tendency despite a burst at the very beginning. The antibacterial properties of GS-laden scaffolds were determined in vitro, and the antibacterial activity of scaffolds was enhanced by incorporating lecithin into PLGA bulks. Additionally, mesenchymal stem cells (MSCs) were seeded onto PLGA-SMS and PLGA/Lec-SMS in vitro. The outcome confirmed PLGA/Lec(5%)-SMS functions to improve MSC proliferation and also to enhance general ALP production and calcium secretion which is the vital markers for osteogenesis. In conclusion, this newly designed antibiotic releasing PLGA/Lec-SMS is promising for bone-repairing therapeutics.

    Original languageEnglish
    Pages (from-to)85-92
    Number of pages8
    JournalInternational Journal of Pharmaceutics
    Volume373
    Issue number1-2
    DOIs
    Publication statusPublished - 2009 May 21

    Keywords

    • Antibacterial
    • Controlled release
    • Lecithin
    • Poly(lactide-co-glycolide)
    • Scaffold

    ASJC Scopus subject areas

    • Pharmaceutical Science

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