A prospective randomized trial for treating stages b2 and c prostate cancer: Radical surgery or irradiation with neoadjuvant endocrine therapy

Shigeo Isaka, Jun Shimazaki, Susumu Akimoto, Kiyoki Okada, Osamu Yoshida, Yoichi Arai, Michiyuki Usami, Toshihiko Kotake, Ken Ichi Tobisu, Tadao Kakizoe, Yasuo Ohashi, Yoshimitsu Sumiyoshi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A randomized clinical trial of neoadjuvant endocrine therapy followed by either surgery or irradiation and a resumption of endocrine therapy for stages B2 and C prostate cancer has been in progress since 1989. A hundred patients entered the trial between 1989 and 1993, and 95 cases were evaluated. Forty-six patients received surgery and 49 were treated with irradiation. Neoadjuvant endocrine therapy for two months resulted in prostate shrinkage and prostate specific antigen lowering. Except for two patients, onedying of a progression of disease and the other of another concurrent cancer, all are alive with an average follow-up term of 25 (range 3-53) months. The good prognostic results obtained from both treatment groups at present seem to be due in part to the neoadjuvant endocrine therapy; but in order to reach a final conclusion further comparisons need to be made.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalJapanese journal of clinical oncology
Volume24
Issue number4
DOIs
Publication statusPublished - 1994 Aug

Keywords

  • Localized prostate cancer
  • Neoadjuvant endocrine therapy
  • Prospective randomized trial
  • Surgery or irradiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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