A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease

Mikio Shoji, Ryozo Kuwano, Takasi Asada, Masaki Imagawa, Susumu Higuchi, Katsuya Urakami, Hiroyuki Arai, Yasuo Ihara

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


To clarify the risk and associated genes of Alzheimer's disease by genome-wide screening, a Japanese study group was organized in 2000 under Yasuo Ihara, Tokyo University, supported by a Grant-in-Aid for Science Research on Priority Areas (C)-Advanced Brain Science Project from Ministry of Education, Culture, Sports, Science and Technology, Japan. This is the first Japanese consortium study under permission of the ethical committees of the enrolled institutes based on the ethics guidelines for human genome/gene analysis research. Ministry of Education, Culture, Sports, Science and Technology Ministry of Health, Labor and Welfare Ministry of Economy, Trade and Industry. In this project, 2,000 genome samples from patients with Alzheimer's disease. 2,000 control subjects, and 200 siblings affected with Alzheimer's disease are collected and analyzed. For this purpose, it is necessary to analyze samples from accurately diagnosed Alzheimer patients and controls using standard criteria for diagnosis and neuropsychological evaluation, which have been confirmed by an evidence-based studying a Japanese population. Here, we propose criteria for the diagnosis and clinical assessment of Alzheimer's disease. This proposal consists of a definition of Alzheimer's disease based on recent advances in research, diagnostic criteria based on DSM-IV, NINCDS-ADRDA and ICD-10, exclusion criteria for other dementia disorders, routine and detailed tests for neuropsychological and laboratory evaluations, criteria for neuroimaging and biomarkers, definitive diagnostic criteria and classification of clinical subtypes.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalClinical Neurology
Issue number2
Publication statusPublished - 2005 Feb


  • Advanced Brain Science Project
  • Alzheimer's disease
  • Diagnosis and clinical assessment
  • Genome-wide screening by the Japanese study group

ASJC Scopus subject areas

  • Clinical Neurology


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