Abstract
A practical total synthesis of both enantiomers of epoxyquinols A and B has been developed. Key reactions are the chromatography-free preparation of an iodolactone by using acryloyl chloride as dienophile in the Diels-Alder reaction of furan, the lipase-mediated kinetic resolution of a cyclohexenol derivative, and a modified procedure for α-iodonation of a cyclohexenone.
Original language | English |
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Pages (from-to) | 9155-9158 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 50 |
DOIs | |
Publication status | Published - 2002 Dec 9 |
Externally published | Yes |
Keywords
- Diels-Alder reaction
- Epoxyquinols A and B
- Lipase
- Resolution
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry