A possible role of Atg8 homologs as a scaffold for signal transduction

Takashi Itoh, Mitsunori Fukuda

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Atg8 and its homologs are essential for autophagosome formation in various species. In animal cells, Atg8 homologs have an additional function in clearance of damaged organelles and bacteria, acting as a landmark for selective autophagy. We have recently shown that OATL1, a Rab-GTPase-activating protein (Rab-GAP), is a novel binding partner of Atg8 homologs in mammalian cells, but to our surprise, it is not a substrate of autophagy. Further analysis indicates that OATL1 is involved in the fusion between autophagosomes and lysosomes through its GAP activity and its Atg8 homolog binding activity. Our findings suggest a novel function of Atg8 homologs as a scaffold for signal transduction that regulates autophagosomal maturation.

    Original languageEnglish
    Pages (from-to)1080-1081
    Number of pages2
    JournalAutophagy
    Volume7
    Issue number9
    DOIs
    Publication statusPublished - 2011 Sep

    Keywords

    • Atg8 homologs
    • Autophagosomal maturation
    • GTPase-activating protein
    • OATL1
    • Rab33B

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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