A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency

Yusaku Tazawa, Daiki Abukawa, Osamu Sakamoto, Ikuo Nagata, Jun Murakami, Toshiyuki Iizuka, Manabu Okamoto, Akihiko Kimura, Takao Kurosawa, Kazuie Iinuma, Keiko Kobayashi, Takeyori Saheki, Toshihiro Ohura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

For this study, we investigated why cholestasis develops into neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), and concluded that primary mitochondrial impairment associated with the delayed maturity of bile acid metabolism may contribute to the occurrence of NICCD.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalHepatology Research
Volume31
Issue number3
DOIs
Publication statusPublished - 2005 Mar

Keywords

  • Citirn deficiency
  • Neonatal cholestasis

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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