A possible mechanism of antidepresant activity of beta-amyrin palmitate isolated from lobelia inflata leaves in the forced swimming test

Anas Subarnas, Takeshi Tadano, Norimichi Nakahata, Yuichiro Arai, Hiroyasu Kinemuchi, Yoshiteru Oshima, Kensuke Kisara, Yasushi Ohizumi

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34 Citations (Scopus)

Abstract

A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyrosine (500 mg/kg). Beta-amyrin palmitate (5 and 10 mg/kg) decreased the duration of immobility in mice treated with desipramine plus 6-hydroxy-dopamine (50 μg/mouse), but did not affect that induced by nomifensine plus 6-hydroxydopamine. The decrease immobility produced by desipramine (15 mg/kg) was not affected by beta-amyrin palmitate. A study of norepinephrine release in mouse brain synaptosomes indicated that beta-amyrin palmitate caused a release of [3H]norepinephrine. The results of the present study suggest that beta-amyrin palmitate might release norepinephrine from newly synthesized pools, and thus, it might activate noradrenergic activity.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalLife Sciences
Volume52
Issue number3
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Subarnas, A., Tadano, T., Nakahata, N., Arai, Y., Kinemuchi, H., Oshima, Y., Kisara, K., & Ohizumi, Y. (1993). A possible mechanism of antidepresant activity of beta-amyrin palmitate isolated from lobelia inflata leaves in the forced swimming test. Life Sciences, 52(3), 289-296. https://doi.org/10.1016/0024-3205(93)90220-W