A porphyrin tetramer for a positive homotropic allosteric recognition system: Efficient binding information transduction through butadiynyl axis rotation

Yohei Kubo, Masato Ikeda, Atsushi Sugasaki, Masayuki Takeuchi, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

Abstract

A porphyrin tetramer 1 was newly designed and synthesized to construct a novel allosteric guest-binding system. Compound 1 has a butadiynyl rotational axis, which is expected to act as a guest-binding information transducer. In chloroform, 1 can bind bidentate amines, such as 1,3-di(4-piperidyl)propane (DPP), in an allosteric manner to produce a 1:2 1/diamine complex with a Hill coefficient of 1.9.

Original languageEnglish
Pages (from-to)7435-7438
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number42
DOIs
Publication statusPublished - 2001 Oct 15
Externally publishedYes

Keywords

  • Allosterism
  • Cooperativity
  • Molecular recognition
  • Porphyrin
  • Rotational axis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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