TY - JOUR
T1 - A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye
AU - Nagai, Nobuhiro
AU - Kaji, Hirokazu
AU - Onami, Hideyuki
AU - Ishikawa, Yumi
AU - Nishizawa, Matsuhiko
AU - Osumi, Noriko
AU - Nakazawa, Toru
AU - Abe, Toshiaki
N1 - Funding Information:
This study was supported by Grant-in-Aid for Young Scientists (A) from the Ministry of Education, Culture, Sports, Science, and Technology 23680054 (N.N.), Health Labour Sciences Research Grant from the Ministry of Health Labour and Welfare H23-iryokiki-wakate-003 (N.N.), H23-kankaku-ippan-004 (T.A. and N.N.), H24-nanchitoh-ippan-067 (T.A. and N.N.), the Takeda Science Foundation (N.N.), the Tohoku University Exploratory Research Program for Young Scientists (N.N.) and Gonryo Medical Foundation (N.N.). We thank T. Kawashima, N. Kumasaka, T. Yamada and S. Ito for help with device molds preparation.
PY - 2014/2
Y1 - 2014/2
N2 - The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover and three different fluorescent formulations, which were made of photopolymeized tri(ethyleneglycol) dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each fluorescent is controlled by varying the PEGDM/TEGDM ratio in its formulation and the cover. The release kinetics appeared to be related to the swelling ratio of the PEGDM/TEGDM polymers. When the devices were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks' implantation and distributed locally around the implantation site. Our polymeric system, which can administer multiple compounds with distinct kinetics, provides prolonged action and less invasive transscleral administration, and is expected to provide new tools for the treatment of posterior eye diseases with new therapeutic modalities.
AB - The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover and three different fluorescent formulations, which were made of photopolymeized tri(ethyleneglycol) dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each fluorescent is controlled by varying the PEGDM/TEGDM ratio in its formulation and the cover. The release kinetics appeared to be related to the swelling ratio of the PEGDM/TEGDM polymers. When the devices were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks' implantation and distributed locally around the implantation site. Our polymeric system, which can administer multiple compounds with distinct kinetics, provides prolonged action and less invasive transscleral administration, and is expected to provide new tools for the treatment of posterior eye diseases with new therapeutic modalities.
KW - Multi-drug delivery
KW - Poly(ethyleneglycol) dimethacrylate
KW - Retina
KW - Transscleral delivery
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U2 - 10.1016/j.actbio.2013.11.004
DO - 10.1016/j.actbio.2013.11.004
M3 - Article
C2 - 24239899
AN - SCOPUS:84896545712
VL - 10
SP - 680
EP - 687
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
IS - 2
ER -