A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats

Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

Original languageEnglish
Pages (from-to)1555-1560
Number of pages6
JournalAdvanced Healthcare Materials
Volume3
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • Edaravone
  • Poly(ethyleneglycol) dimethacrylate
  • Retina
  • Transscleral drug delivery
  • Unoprostone

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats'. Together they form a unique fingerprint.

Cite this