A pilot study of Banxia Houpu Tang, a traditional Chinese medicine, for reducing pneumonia risk in older adults with dementia

Koh Iwasaki, Shiro Kato, Yasutake Monma, Kaijun Niu, Takashi Ohrui, Reina Okitsu, Satoshi Higuchi, Shiro Ozaki, Noboru Kaneko, Takashi Seki, Katsutoshi Nakayama, Katsutoshi Furukawa, Masahiko Fujii, Hiroyuki Arai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVES: To evaluate whether the traditional Chinese herbal medicine Banxia Houpu Tang (BHT, formula magnolia et pinelliae) prevents aspiration pneumonia and pneumonia-related mortality in elderly people. DESIGN: A prospective, observer-blinded, randomized, controlled trial. SETTING: Two long-term care hospitals for handicapped elderly patients in Japan from March 2005 to February 2006. PARTICIPANTS: One hundred four elderly patients (31 men and 73 women; mean age±standard deviation 83.5±7.8) with dementia and cerebrovascular disease, Alzheimer's disease, or Parkinson's disease. INTERVENTION: Ninety-five participants (mean age 84.0, M:F=28:67) were randomly assigned to the BHT treatment group (n=47) or the control group (n=48) and took BHT or placebo for 12 months. MEASUREMENTS: The occurrence of pneumonia, mortality due to pneumonia, and the daily amount of self-feeding. RESULTS: Complete data were available for analysis on 92 of the 95 subjects randomized. Four patients in the BHT group developed pneumonia, and one of them died as a result. Fourteen patients in the control group developed pneumonia, and six of them died as a result. There was a significant difference between the two groups in pneumonia onset (P=.008), and a tendency toward significance in pneumonia-related mortality (P=.05). The relative risk of pneumonia in the BHT group compared with the control group was 0.51 (95% confidence interval (CI)=0.27-0.84, P=.008) and that of death from pneumonia was 0.41 (95% CI=0.10-1.03, P=.06) according to the Cox proportional hazards model. No adverse events were observed from treatment with BHT. The BHT group was able to maintain self-feeding better than the control group (P=.006). CONCLUSION: Treatment with BHT reduced the risk of pneumonia and pneumonia-related mortality in elderly patients with dementia.

Original languageEnglish
Pages (from-to)2035-2040
Number of pages6
JournalJournal of the American Geriatrics Society
Volume55
Issue number12
DOIs
Publication statusPublished - 2007 Dec 1

Keywords

  • Aspiration pneumonia
  • Banxia Houpu Tang
  • Complementary medicine
  • Elderly
  • Traditional medicine

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'A pilot study of Banxia Houpu Tang, a traditional Chinese medicine, for reducing pneumonia risk in older adults with dementia'. Together they form a unique fingerprint.

  • Cite this

    Iwasaki, K., Kato, S., Monma, Y., Niu, K., Ohrui, T., Okitsu, R., Higuchi, S., Ozaki, S., Kaneko, N., Seki, T., Nakayama, K., Furukawa, K., Fujii, M., & Arai, H. (2007). A pilot study of Banxia Houpu Tang, a traditional Chinese medicine, for reducing pneumonia risk in older adults with dementia. Journal of the American Geriatrics Society, 55(12), 2035-2040. https://doi.org/10.1111/j.1532-5415.2007.01448.x