A Photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement

Yangyang Yang, Ryu Tashiro, Yuki Suzuki, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Masayuki Endo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Various DNA-based nanodevices have been developed on the nanometer scale using light as regulation input. However, the programmed controllability is still a major challenge for these artificial nanodevices. Herein, we demonstrate a rotary DNA nanostructure in which the rotations are controlled by light. A bar-shaped DNA rotor, fabricated as a stiff double-crossover molecule, was placed on the top of a rectangular DNA tile. The photoresponsive oligonucleotides modified with azobenzenes were employed as switching motifs to release/trap the rotor at specific angular position on DNA tile by switching photoirradiations between ultraviolet and visible light. As a result, two reconfigurable states (perpendicular and parallel) of rotor were obtained, in which the angular changes were characterized by AFM and fluorescence quenching assays. Moreover, the reversible rotary motions during the photoirradiation were directly visualized on the DNA tile surface in a nanometer-scale precision using a second-scale scanning of the high-speed AFM.

Original languageEnglish
Pages (from-to)3979-3985
Number of pages7
JournalChemistry - A European Journal
Volume23
Issue number16
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • DNA
  • high-speed AFM
  • molecular wires
  • nanotechnology
  • photochemistry

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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