TY - JOUR
T1 - A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia?
AU - Ohrui, Takashi
AU - Higuchi, Makoto
AU - Kanda, Akio
AU - Matsui, Toshifumi
AU - Sato, Emi
AU - Sasaki, Hidetada
N1 - Copyright:
Copyright 2005 Elsevier B.V., All rights reserved.
PY - 2001/3
Y1 - 2001/3
N2 - This report presents the case of a patient with corticosteroid and cyclophosphamide resistant exacerbation of idiopathic pulmonary fibrosis (IPF), which was definitely resolved in accordance with increased levels of serum conjugated bilirubin due to biliary tract obstruction. Histological examination of the lung showed an accumulation of bile pigments in the alveolar mural tissues, especially in the cytoplasm of the alveolar macrophages, which play crucial roles in the development of IPF. This case suggests that bile pigments have some important roles in tissue protection against inflammatory damage in IPF, and may illustrate an important key for treatment of this fatal disorder.
AB - This report presents the case of a patient with corticosteroid and cyclophosphamide resistant exacerbation of idiopathic pulmonary fibrosis (IPF), which was definitely resolved in accordance with increased levels of serum conjugated bilirubin due to biliary tract obstruction. Histological examination of the lung showed an accumulation of bile pigments in the alveolar mural tissues, especially in the cytoplasm of the alveolar macrophages, which play crucial roles in the development of IPF. This case suggests that bile pigments have some important roles in tissue protection against inflammatory damage in IPF, and may illustrate an important key for treatment of this fatal disorder.
KW - Alveolitis
KW - Antioxidant activity
KW - Conjugated bilirubin
KW - Reactive oxygen species
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U2 - 10.1620/tjem.193.245
DO - 10.1620/tjem.193.245
M3 - Article
C2 - 11315772
AN - SCOPUS:0035292954
VL - 193
SP - 245
EP - 249
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 3
ER -