TY - JOUR
T1 - A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor
AU - Tsujimoto, Tetsuro
AU - Takaichi, Maki
AU - Endo, Hisako
AU - Yasuda, Kazuki
AU - Kishimoto, Miyako
AU - Noto, Hiroshi
AU - Gomibuchi, Hideto
AU - Yasuda, Hidemitsu
AU - Yamamoto-Honda, Ritsuko
AU - Takahashi, Yoshihiko
AU - Kajio, Hiroshi
AU - Sasano, Hironobu
AU - Noda, Mitsuhiko
PY - 2011/1/1
Y1 - 2011/1/1
N2 - A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.
AB - A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.
KW - Breast cancer
KW - Brenner tumor
KW - Mature cystic teratoma
KW - Testosterone
KW - Virilization
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U2 - 10.1097/MAJ.0b013e3181f54e59
DO - 10.1097/MAJ.0b013e3181f54e59
M3 - Article
C2 - 20924286
AN - SCOPUS:78651314018
VL - 341
SP - 74
EP - 77
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 1
ER -