A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor

Tetsuro Tsujimoto; Maki Takaichi; Hisako Endo; Kazuki Yasuda; Miyako Kishimoto; Hiroshi Noto; Hideto Gomibuchi; Hidemitsu Yasuda; Ritsuko Yamamoto-Honda; Yoshihiko Takahashi; Hiroshi Kajio; Hironobu Sasano; Mitsuhiko Noda

doi:10.1097/MAJ.0b013e3181f54e59

A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor

Tetsuro Tsujimoto, Maki Takaichi, Hisako Endo, Kazuki Yasuda, Miyako Kishimoto, Hiroshi Noto, Hideto Gomibuchi, Hidemitsu Yasuda, Ritsuko Yamamoto-Honda, Yoshihiko Takahashi, Hiroshi Kajio, Hironobu Sasano, Mitsuhiko Noda

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.

Original language	English
Pages (from-to)	74-77
Number of pages	4
Journal	American Journal of the Medical Sciences
Volume	341
Issue number	1
DOIs	https://doi.org/10.1097/MAJ.0b013e3181f54e59
Publication status	Published - 2011 Jan 1
Externally published	Yes

Keywords

Breast cancer
Brenner tumor
Mature cystic teratoma
Testosterone
Virilization

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MAJ.0b013e3181f54e59

Cite this

Tsujimoto, T., Takaichi, M., Endo, H., Yasuda, K., Kishimoto, M., Noto, H., Gomibuchi, H., Yasuda, H., Yamamoto-Honda, R., Takahashi, Y., Kajio, H., Sasano, H., & Noda, M. (2011). A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor. American Journal of the Medical Sciences, 341(1), 74-77. https://doi.org/10.1097/MAJ.0b013e3181f54e59

Tsujimoto, T, Takaichi, M, Endo, H, Yasuda, K, Kishimoto, M, Noto, H, Gomibuchi, H, Yasuda, H, Yamamoto-Honda, R, Takahashi, Y, Kajio, H, Sasano, H & Noda, M 2011, 'A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor', American Journal of the Medical Sciences, vol. 341, no. 1, pp. 74-77. https://doi.org/10.1097/MAJ.0b013e3181f54e59

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abstract = "A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.",

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AU - Takaichi, Maki

AU - Endo, Hisako

AU - Yasuda, Kazuki

AU - Kishimoto, Miyako

AU - Noto, Hiroshi

AU - Gomibuchi, Hideto

AU - Yasuda, Hidemitsu

AU - Yamamoto-Honda, Ritsuko

AU - Takahashi, Yoshihiko

AU - Kajio, Hiroshi

AU - Sasano, Hironobu

AU - Noda, Mitsuhiko

PY - 2011/1/1

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N2 - A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.

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KW - Testosterone

KW - Virilization

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A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a brenner tumor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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