A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model

Yuichiro Miura, Tadashi Matsuda, Haruo Usuda, Shimpei Watanabe, Ryuta Kitanishi, Masatoshi Saito, Takushi Hanita, Yoshiyasu Kobayashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

An artificial placenta (AP) is an arterio-venous extracorporeal life support system that is connected to the fetal circulation via the umbilical vasculature. Previously, we published an article describing a pumpless AP system with a small priming volume. We subsequently developed a parallelized system, hypothesizing that the reduced circuit resistance conveyed by this modification would enable healthy fetal survival time to be prolonged. We conducted experiments using a premature lamb model to test this hypothesis. As a result, the fetal survival period was significantly prolonged (60.4±3.8 vs. 18.2±3.2h, P<0.01), and circuit resistance and minimal blood lactate levels were significantly lower in the parallel circuit group, compared with our previous single circuit group. Fetal physiological parameters remained stable until the conclusion of the experiments. In summary, parallelization of the AP system was associated with reduced circuit resistance and lactate levels and allowed preterm lamb fetuses to survive for a significantly longer period when compared with previous studies.

Original languageEnglish
Pages (from-to)E61-E68
JournalArtificial Organs
Volume40
Issue number5
DOIs
Publication statusPublished - 2016 May 1

Keywords

  • Artificial placenta
  • Parallelized circuit
  • Preterm lamb model

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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