A one-pot copper catalyzed biomimetic route to n -heterocyclic amides from methyl ketones via oxidative c-c bond cleavage

Parthasarathi Subramanian, Satrajit Indu, Krishna P. Kaliappan

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

A direct one-pot Cu-catalyzed biomimetic oxidation of methyl ketones to pharmaceutically important N-heterocyclic amides is reported. The scope of the method is broad, scalable, and mild, and the reaction is tolerant with various acid, base sensitive functionalities with multiple heteroatoms and aryl halides. The extensive mechanistic studies suggest that this reaction follows the Luciferin-Luciferase-like pathway.

Original languageEnglish
Pages (from-to)6212-6215
Number of pages4
JournalOrganic letters
Volume16
Issue number23
DOIs
Publication statusPublished - 2014 Dec 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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