TY - JOUR
T1 - A novel type of human α-amylase produced in lung carcinoid tumor
AU - Tomita, Naohiro
AU - Akira, Horii
AU - Sadayuki, Doi
AU - Hideoki, Yokouchi
AU - Kouichi, Shiosaki
AU - Masahiko, Higashiyama
AU - Nariaki, Matsuura
AU - Michio, Ogawa
AU - Takesada, Mori
AU - Kenichi, Matsubara
PY - 1989/3/15
Y1 - 1989/3/15
N2 - A novel type of α-amylase was detected in a lung carcinoid tissue after surveying the cDNA library constructed from this tumor mRNA. Nucleotide sequence analysis showed that the amylase expressed in this carcinoid tumor has 13 and 6 amino acid substitutions when compared with salivary amylase (Amy1) and pancreatic amylase (Amy2), respectively. The nucleotide sequence homologies of cDNAs between this carcinoid amylase and amy1, amy2 are 97.5% and 98.2%, respectively. The nucleotide sequence comparison strongly suggests that this new amylase is the product of the amy3 gene that has been detected in human genome [Emi et al., Gene 62 (1988) 229-235].
AB - A novel type of α-amylase was detected in a lung carcinoid tissue after surveying the cDNA library constructed from this tumor mRNA. Nucleotide sequence analysis showed that the amylase expressed in this carcinoid tumor has 13 and 6 amino acid substitutions when compared with salivary amylase (Amy1) and pancreatic amylase (Amy2), respectively. The nucleotide sequence homologies of cDNAs between this carcinoid amylase and amy1, amy2 are 97.5% and 98.2%, respectively. The nucleotide sequence comparison strongly suggests that this new amylase is the product of the amy3 gene that has been detected in human genome [Emi et al., Gene 62 (1988) 229-235].
KW - Kultschitzky cell
KW - Recombinant DNA
KW - amylase isozyme
KW - cDNA
KW - phage λ vectors
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U2 - 10.1016/0378-1119(89)90003-6
DO - 10.1016/0378-1119(89)90003-6
M3 - Article
C2 - 2701942
AN - SCOPUS:0024500739
VL - 76
SP - 11
EP - 18
JO - Gene
JF - Gene
SN - 0378-1119
IS - 1
ER -