A novel translocation involving chromosomes 2, 9, 14, and 22 in chronic myeloid leukemia

Kazuyasu Endo, Akiyoshi Sato, Tomohiro Sugawara, Junichi Kameoka, Osamu Fukuhara, Kuniaki Meguro, Tomoaki Shishido, Keishi Abe

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A 46-year-old man with chronic myelogenous leukemia was found to have a new complex translocation. In chronic phase, all of the bone marrow cells had a rearrangement of a t(2;9;14;22) (p21;q34;q32;q11). Southern blot analysis of leukocyte DNA revealed rearrangement of the breakpoint cluster region (bcr) within the 5.8-Kb bcr. The patient eventually died in blast crisis 28 months later. The cytogenetic findings of bone marrow cells showed a 46,XY,t(2;9;14;22)(p21;q34;q32;qll),add(lp),del(3q) karyotype in blast crisis.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume80
Issue number2
DOIs
Publication statusPublished - 1995 Apr

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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