A NOVEL STRUCTURE DESIGN of BIODEGRADABLE ZINC ALLOY STENT and ITS EFFECTS on RESHAPING STENOTIC VESSEL

K. U.N. Peng, Aike Qiao, Junjie Wang, Makoto Ohta, Xinyang Cui, Yongliang Mu

Research output: Contribution to journalArticlepeer-review

Abstract

Biodegradable zinc alloy stents offer a prospective solution to mitigate incompatibility between artery and permanent stents. However, biodegradable stents are restricted in clinical therapy mainly because of their insufficient support for opening of stenotic vessel. As an effort to resolve this challenging problem, a novel structure of zinc alloy stent which significantly enhanced scaffold performance is proposed in this paper. Subsequently, the functionality of the new stent on reshaping vessels with 40% of stenosis was investigated in contrast with a common stent via finite element analysis. The simulation results show that radial recoiling ratio and dog-boning ratio of the new stent are decreased by 43.2% and 16.3%, respectively, compared with those of the common stent. A larger and flatter lumen is found in the plaque-vessel system deployed with the new stent. It suggests that the geometry of stent has strong influence on its mechanical performance. With strong scaffold capability and brilliant effect on reshaping stenotic vessel, the biodegradable zinc alloy stent-based novel structure is highly promised to be an alternative choice in interventional surgeries.

Original languageEnglish
Article number2050022
JournalJournal of Mechanics in Medicine and Biology
Volume20
Issue number6
DOIs
Publication statusPublished - 2020 Aug 1

Keywords

  • Biodegradable stent
  • biomechanics
  • finite element analysis
  • stenosis

ASJC Scopus subject areas

  • Biomedical Engineering

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