A novel strategy for the automated synthesis of bis-amides of 1,2- diamines

Takayuki Doi; Ichiro Hijikuro; Takashi Takahashi

doi:10.1055/s-1999-2947

A novel strategy for the automated synthesis of bis-amides of 1,2- diamines

Takayuki Doi, Ichiro Hijikuro, Takashi Takahashi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.

Original language	English
Pages (from-to)	1751-1753
Number of pages	3
Journal	Synlett
Issue number	11
DOIs	https://doi.org/10.1055/s-1999-2947
Publication status	Published - 1999
Externally published	Yes

Keywords

Amides
Amines
Combinatorial chemistry
Condensation
Solid-phase synthesis

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-1999-2947

Cite this

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abstract = "An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.",

keywords = "Amides, Amines, Combinatorial chemistry, Condensation, Solid-phase synthesis",

author = "Takayuki Doi and Ichiro Hijikuro and Takashi Takahashi",

year = "1999",

doi = "10.1055/s-1999-2947",

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AU - Doi, Takayuki

AU - Hijikuro, Ichiro

AU - Takahashi, Takashi

PY - 1999

Y1 - 1999

N2 - An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.

AB - An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.

KW - Amides

KW - Amines

KW - Combinatorial chemistry

KW - Condensation

KW - Solid-phase synthesis

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DO - 10.1055/s-1999-2947

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JF - Synlett

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IS - 11

ER -

A novel strategy for the automated synthesis of bis-amides of 1,2- diamines

Abstract

Keywords

ASJC Scopus subject areas

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