A novel strategy for the automated synthesis of bis-amides of 1,2- diamines

Takayuki Doi, Ichiro Hijikuro, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.

Original languageEnglish
Pages (from-to)1751-1753
Number of pages3
JournalSynlett
Issue number11
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

Keywords

  • Amides
  • Amines
  • Combinatorial chemistry
  • Condensation
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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