A novel strategy for reversible control of conformation and DNA/RNA recognition of peptide ribonucleic acid (PRNA) by external factors.

Takehiko Wada, Hirofumi Sato, Yoshihisa Inoue

Research output: Contribution to journalArticle

Abstract

A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5'-amino-5'-deoxyribonucleoside as a recognition site for nucleic acids, has been designed, synthesized and applied to the external reversible control of recognition behavior of the complementary oligomeric DNA through the orientational switching of the nucleobase induced by borates. In case of PRNA 12-mers, efficient orientational change of nucleobases was observed. Furthermore, these oligomeric PRNAs form a stable complex with complementary DNA's and the recognition behavior of oligomeric PRNAs with DNA's is controlled by the borate added as an external factor.

Original languageEnglish
Pages (from-to)213-214
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
DOIs
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Medicine(all)

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