A Novel Somatic Point Mutation of the RET Proto‐oncogene in Tumor Tissues of Small Cell Lung Cancer Patients

Hitoyasu Futami, Shin‐ichi ‐i Egawa, Toshihiko Tsukada, Kouji Maruyama, Shuji Bandoh, Masayuki Noguchi, Ken Yamaguchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined whether the novel point mutation from GCC (Ala) to GAC (Asp) at codon 664 in exon 11 of RET proto‐oncogene, which we had found in two small cell lung carcinoma (SCLC) cell lines, existed in genomic DNA of tumor tissues of the two SCLC patients from whom these SCLC cell lines were derived. Sequence analysis revealed that point mutation identical to that of the SCLC cell lines was present in amplified alleles of single‐strand conformational variants in genomic DNA of the tumor tissues, whereas it was not detected in genomic DNA of non‐tumor tissues of the patients. These results indicate that this mutation had initially occurred in the SCLC patients and was of somatic origin.

Original languageEnglish
Pages (from-to)1127-1130
Number of pages4
JournalJapanese Journal of Cancer Research
Volume86
Issue number12
DOIs
Publication statusPublished - 1995 Dec

Keywords

  • Medullary thyroid carcinoma
  • Multiple endocrine neoplasia
  • Point mutation
  • RET
  • Small cell lung carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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