Abstract
The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoid arthritis. In this study, we analyzed all the exons and exon/intron junctions of the MTHFR gene from 200 Japanese individuals. We detected a novel single nucleotide polymorphism (SNP) 148C>T (Arg46Trp) in exon 1. The allele frequency of this polymorphism in the Japanese population appears to be extremely low (0.25%).
Original language | English |
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Pages (from-to) | 387-390 |
Number of pages | 4 |
Journal | Drug metabolism and pharmacokinetics |
Volume | 20 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2005 Oct |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Pharmacology (medical)