A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo

Taichiro Takemura; Michel Ekwalanga; Blaise Bikandou; Eiji Ido; Yumi Yamaguchi-Kabata; Sadayuki Ohkura; Hirotada Harada; Jun Takehisa; Hiroshi Ichimura; Henri Joseph Parra; Monique Nende; Eric Mubwo; Midingi Sepole; Masanori Hayami; Tomoyuki Miura

doi:10.1099/vir.0.80697-0

A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo

Taichiro Takemura, Michel Ekwalanga, Blaise Bikandou, Eiji Ido, Yumi Yamaguchi-Kabata, Sadayuki Ohkura, Hirotada Harada, Jun Takehisa, Hiroshi Ichimura, Henri Joseph Parra, Monique Nende, Eric Mubwo, Midingi Sepole, Masanori Hayami, Tomoyuki Miura

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.

Original language	English
Pages (from-to)	1967-1971
Number of pages	5
Journal	Journal of General Virology
Volume	86
Issue number	7
DOIs	https://doi.org/10.1099/vir.0.80697-0
Publication status	Published - 2005 Jul

ASJC Scopus subject areas

Virology

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Takemura, T., Ekwalanga, M., Bikandou, B., Ido, E., Yamaguchi-Kabata, Y., Ohkura, S., Harada, H., Takehisa, J., Ichimura, H., Parra, H. J., Nende, M., Mubwo, E., Sepole, M., Hayami, M., & Miura, T. (2005). A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo. Journal of General Virology, 86(7), 1967-1971. https://doi.org/10.1099/vir.0.80697-0

A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo. / Takemura, Taichiro; Ekwalanga, Michel; Bikandou, Blaise; Ido, Eiji; Yamaguchi-Kabata, Yumi; Ohkura, Sadayuki; Harada, Hirotada; Takehisa, Jun; Ichimura, Hiroshi; Parra, Henri Joseph; Nende, Monique; Mubwo, Eric; Sepole, Midingi; Hayami, Masanori; Miura, Tomoyuki.

In: Journal of General Virology, Vol. 86, No. 7, 07.2005, p. 1967-1971.

Research output: Contribution to journal › Article › peer-review

Takemura, T, Ekwalanga, M, Bikandou, B, Ido, E, Yamaguchi-Kabata, Y, Ohkura, S, Harada, H, Takehisa, J, Ichimura, H, Parra, HJ, Nende, M, Mubwo, E, Sepole, M, Hayami, M & Miura, T 2005, 'A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo', Journal of General Virology, vol. 86, no. 7, pp. 1967-1971. https://doi.org/10.1099/vir.0.80697-0

Takemura, Taichiro ; Ekwalanga, Michel ; Bikandou, Blaise ; Ido, Eiji ; Yamaguchi-Kabata, Yumi ; Ohkura, Sadayuki ; Harada, Hirotada ; Takehisa, Jun ; Ichimura, Hiroshi ; Parra, Henri Joseph ; Nende, Monique ; Mubwo, Eric ; Sepole, Midingi ; Hayami, Masanori ; Miura, Tomoyuki. / A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo. In: Journal of General Virology. 2005 ; Vol. 86, No. 7. pp. 1967-1971.

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abstract = "In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.",

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