TY - JOUR
T1 - A novel simian immunodeficieny virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo
AU - Takemura, Taichiro
AU - Ekwalanga, Michel
AU - Bikandou, Blaise
AU - Ido, Eiji
AU - Yamaguchi-Kabata, Yumi
AU - Ohkura, Sadayuki
AU - Harada, Hirotada
AU - Takehisa, Jun
AU - Ichimura, Hiroshi
AU - Parra, Henri Joseph
AU - Nende, Monique
AU - Mubwo, Eric
AU - Sepole, Midingi
AU - Hayami, Masanori
AU - Miura, Tomoyuki
PY - 2005/7
Y1 - 2005/7
N2 - In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.
AB - In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.
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U2 - 10.1099/vir.0.80697-0
DO - 10.1099/vir.0.80697-0
M3 - Article
C2 - 15958675
AN - SCOPUS:21444460906
VL - 86
SP - 1967
EP - 1971
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
IS - 7
ER -
