A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells

Masahiro Yanagisawa, Yousuke Mukouyama, Toshio Watanabe, Masuo Obinata, Yasuhisa Matsui

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We have isolated a novel serine/threonine kinase gene designated Gek1 from mouse primordial germ cell-derived embryonic germ cell. Gek1 is preferentially expressed in meiotic testicular germ cells and primordial germ cells. Gek1 mRNA is also detected in several other tissues, including hematopoietic organs in adult mice and central nervous system in embryos. The Gek1 cDNA encodes a protein with the consensus sequence of the catalytic domain of protein kinases in its N-terminal region. The deduced amine acid sequence of Gek1 in the kinase domain is related to those encoded by the Saccharomyces cerevisiae STE20, CDC15, and Drosophila melanogaster ninaC. The patterns of expression and the structural features of GekJ suggest that the gene product is involved in signal transduction or nuclear division of germ cells and other proliferating cells. We also show that Gek1 locates on chromosome 11, near the wr locus, showing neuronal and reproductive defects.

Original languageEnglish
Pages (from-to)411-420
Number of pages10
JournalMolecular reproduction and development
Volume45
Issue number4
DOIs
Publication statusPublished - 1996 Dec 1

Keywords

  • Embryogenesis
  • Gek1
  • Meiosis
  • Primordial germ cells
  • Serine/threonine kinase

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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