A novel role for hGas7b in microtubular maintenance: Possible implication in Tau-associated pathology in Alzheimer disease

Hirotada Akiyama, Aina Gotoh, Ryong Woon Shin, Tomoe Koga, Tsubasa Ohashi, Wataru Sakamoto, Akihiro Harada, Hiroyuki Arai, Akira Sawa, Chiyoko Uchida, Takafumi Uchida

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptidyl prolyl cis/trans isomerase, Pin1, that facilitates microtubule assembly. Thus, we have demonstrated that hGas7b binds Tau at the WW motif and that the hGas7b/Tau protein complex interacts with the microtubules, promoting tubulin polymerization. Tau, in turn, contributes to protein stability of hGas7b. Furthermore, we observed decreased levels of hGas7b in the brains from patients with Alzheimer disease. These results suggest an important role for hGas7b in microtubular maintenance and possible implication in Alzheimer disease.

Original languageEnglish
Pages (from-to)32695-32699
Number of pages5
JournalJournal of Biological Chemistry
Volume284
Issue number47
DOIs
Publication statusPublished - 2009 Nov 20

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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