TY - JOUR
T1 - A novel recognition system for MHC class I molecules constituted by PIR
AU - Takai, Toshiyuki
N1 - Funding Information:
The author's work cited in the present review is supported by the CREST Program of Japan Science and Technology Agency and by research grants from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2005
Y1 - 2005
N2 - The paired immunoglobulin (Ig)-like receptors (PIRs) represent a typical receptor pair of the Ig-like receptor family in which various combinations of ligand-receptor interaction provide a positive and negative regulation of immune cells, thus enabling those cells to respond properly to extrinsic stimuli. Activating PIR-A and inhibitory PIR-B are expressed in a wide range of cells in the murine immune system, such as B cells, mast cells, macrophages, and dendritic cells, mostly in a pair-wise fashion. PIRs bind to MHC class I molecules expressed ubiquitously on hematopoietic as well as nonhematopoietic cells. The unbalanced binding of PIR-A and PIR-B to MHC class I molecules may lead to the perturbation of cell development, regulation, and function as observed in PIR-B-deficient mice. Thus, PIR-A and PIR-B are indispensable for the regulation of cellular signaling and important for homeostasis of the immune system.
AB - The paired immunoglobulin (Ig)-like receptors (PIRs) represent a typical receptor pair of the Ig-like receptor family in which various combinations of ligand-receptor interaction provide a positive and negative regulation of immune cells, thus enabling those cells to respond properly to extrinsic stimuli. Activating PIR-A and inhibitory PIR-B are expressed in a wide range of cells in the murine immune system, such as B cells, mast cells, macrophages, and dendritic cells, mostly in a pair-wise fashion. PIRs bind to MHC class I molecules expressed ubiquitously on hematopoietic as well as nonhematopoietic cells. The unbalanced binding of PIR-A and PIR-B to MHC class I molecules may lead to the perturbation of cell development, regulation, and function as observed in PIR-B-deficient mice. Thus, PIR-A and PIR-B are indispensable for the regulation of cellular signaling and important for homeostasis of the immune system.
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U2 - 10.1016/S0065-2776(05)88005-8
DO - 10.1016/S0065-2776(05)88005-8
M3 - Review article
C2 - 16227090
AN - SCOPUS:26444493671
VL - 88
SP - 161
EP - 192
JO - Advances in Immunology
JF - Advances in Immunology
SN - 0065-2776
ER -