A novel protein containing cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes

Tohru Yamakuni, Toshifumi Yamamoto, Masato Hoshino, Si Young Song, Hideko Yamamoto, Mayuko Kunikata-Sumitomo, Atsuko Minegishi, Misae Kubota, Mieko Ito, Shiro Konishi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Catecholaminergic (dopaminergic, noradrenergic, and adrenergic) transmitter phenotypes require the cooperative actions of four biosynthetic enzymes: tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine β-hydroxylase, and phenylethanolamine N-methyltransferase. Mechanisms that control expression of these enzymes in a transmitter phenotype-specific manner, however, are poorly understood. Here, we provide evidence that overexpression of a novel cdc10/SWI6 motif-containing protein, V-1, elicits the coordinate up-regulation of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and dopamine β-hydroxylase mRNAs in the neuronal cell line PC12D, and as a result, catecholamine levels are increased. Furthermore, V-1 is strongly expressed in the cytoplasm of rat chromaffin cells of adrenal medulla. Thus, V-1 may act as a cytoplasmic protein/protein adapter and be involved in control of the catecholaminergic phenotype expression via an intracellular pathway signaling to the nucleus.

Original languageEnglish
Pages (from-to)27051-27054
Number of pages4
JournalJournal of Biological Chemistry
Volume273
Issue number42
DOIs
Publication statusPublished - 1998 Oct 16

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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